PYQs GPAT 2021

1. Which ointment base ingredient is part of an absorption base?

2. A fluid whose apparent volume increases under shear exhibits:

3. Formaldehyde plus a Grignard reagent yields:

4. Post-marketing safety studies are conducted in which phase?

5. How many stereoisomers are possible for 3-bromo-2-butanol?

6. Which form is used to import small quantities of drugs for personal use?

7. Inhibition of T4 to T3 conversion is associated with:

8. In Mier's theory of supersaturation, which solute's curve is used as a model?

9. In healing of an excised wound, there is:

10. Which tissue shows the least drug binding in an antivascular context?

11. Cyclosporine’s immunosuppression is due to:

12. Which herbal drug classification best reflects its biosynthetic pathway?

13. Assertion: Asava contains self‐generated alcohol. Reason: Its production involves calcination. Choose the correct relation.

14. Which statement about the HMP shunt is false?

15. Which calcium channel blocker most strongly depresses AV nodal conduction?

16. Sedimentation efficiency (S) is defined as:

17. Cyclothiazide has which substituent at C-3 of the benzothiadiazine nucleus?

18. Which plexus is part of the CNS?

19. For depot injections (released over weeks/months), which study design is used?

20. Which of the following is a half-reaction?

21. Which reagent protects the amine group in peptide synthesis?

22. Which drug is not orally absorbed and is not a bronchodilator?

23. A condition with severe extracellular fluid loss (e.g. hemorrhage, diarrhea) is:

24. Which is NOT a gene insertion technique in eukaryotic cells?

25. Which part of a prescription means 'take thou'?

26. In the Gambir-fluorescin test, the petroleum spirit layer shows:

27. Enhancing solubility by adding a water-miscible solvent is called:

28. The proton NMR spectrum of 2,2-dimethylpropane is a:

29. An epoxy ring is prepared by:

30. Immunity from inoculation with live attenuated organisms is:

31. Which ring is present in strychnine?

32. Which technique does NOT determine protein structure?

33. A hypertensive patient on drug 'X' has reduced efficacy when combined with a TCA. 'X' is:

34. Long-term thiazide use in hypertension does NOT cause:

35. A change in which excipient affects tablet dissolution?

36. Which nucleus is observable by NMR spectroscopy?

37. Hydrogenation of pyridine (Pt, 25°C, 3 atm) yields:

38. Which microbial form is most resistant to disinfection?

39. For C13H9N2O4BrS, the hydrogen deficiency index (HDI) is:

40. Which method is used to determine osmotic pressure?

41. Hemophilia A is caused by a deficiency of which clotting factor?

42. Assertion: Gram-negative bacteria fail to retain the primary stain (crystal violet). Reason: Their LPS-rich outer membrane prevents stain retention. Choose:

43. Based on UV data, ephedrine HCl concentration is approx.:

44. Chronic purgative abuse is associated with all EXCEPT:

45. Cyclization of glucose to a pyranose form produces diastereomers called:

46. Which equation describes drug dissolution rate from a tablet?

47. Which substituent on benzoic acid weakens acidity?

48. HEPA filters must remove at least ____% of particles of ____ µm diameter:

49. A fully saturated four-membered heterocycle with one oxygen is called:

50. Which equation relates vapor pressure to absolute temperature?

51. How many facial bones are in an adult human face?

52. A competitive antagonist at the benzodiazepine site is:

53. The purpose of a seal coating in sugar-coated tablets is to:

54. Product positioning involves:

55. What is the typical time distribution (in sec) for the cardiac cycle phases (VS, VD, AS, AD)?

56. The 'Compendium of Pharmaceuticals and Specialties' is published by:

57. Which is NOT an endogenous opioid peptide?

58. Under the Drugs and Cosmetic Act, 1940, drug inspectors’ powers are defined in:

59. Which alkaloid contains an isoquinoline nucleus?

60. Which product life-cycle phase indicates market saturation?

61. Silver nitrate is used in the IP limit test for:

62. Mixed micelles of lipids, bile acids, and vitamins are absorbed by:

63. p-glycoprotein (p-gp) is highly expressed on:

64. At which concentration do surfactant solution properties change sharply?

65. A 3-year-old with influenza should avoid aspirin due to risk of:

66. Desmethyl diazepam (half-life >40 hrs) is a metabolite of:

67. Which statement about antidiabetic drugs is correct?

68. In a Dynamic Vapor Sorption (DVS) isotherm, what is plotted?

69. Which drug can be imported without a license?

70. What is the typical size (in Å) of aqueous-filled pores in membranes?

71. Which is not typically a calibration parameter for a UV-visible spectrophotometer?

72. Which is a non-epithelial malignancy?

73. Which is NOT an intensive property?

74. Which is a misconception about marker compound analysis in herbal drugs?

75. Distribution of which drugs is perfusion‐rate limited?

76. Enzymes using oxygen as hydrogen acceptor are called:

77. Preservatives are usually NOT added to:

78. Which ICH guideline addresses stability testing (bracketing/matrixing)?

79. Beta-oxidation of palmitic acid produces how many acetyl-CoA?

80. The 'wheal and flare' reaction indicates which hypersensitivity type?

81. A substituent’s strongest effect on an aromatic ring occurs at:

82. Which is an unorganized (crude) drug?

83. Prostaglandin analogs are used in all EXCEPT:

84. Which drug is an ansamycin antibiotic?

85. Which drug dimerizes in aqueous solution to form a diketopiperazine?

86. For a drug (initial concentration 28 units/mL) following first‐order kinetics, the half-life is approximately:

87. The USP term for alcoholic liquid preparations of vegetable drugs is:

88. A hospital formulary is a list of:

89. WHO guidelines for herbal drugs set heavy metal limits for:

90. For 1,3-butadiene, how many π molecular orbitals form?

91. Which cation has the lowest molar ionic conductivity at infinite dilution?

92. What is the value of R (gas constant) for activation energy?

93. In chronic bronchitis/bronchiectasis, pseudostratified epithelium converts to which type?

94. Name the popular membrane-controlled ocular pilocarpine device:

95. Dehydration of the aldol product of two acetaldehyde molecules via E1cb gives:

96. Total amino acids in human insulin (A and B chains)?

97. A β₁/β₂ agonist acting at the AV node increases:

98. Light-directed synthesis on silica wafers is part of:

99. Chitosan is known for which properties?

100. Assertion: Gram-negative bacteria fail to retain crystal violet. Reason: LPS-rich membrane prevents stain retention. Choose:

101. Very weak acidic drugs (pKa >8) are:

102. Which of the following is a Class I residual solvent per ICH guidelines?

103. Which apparatus measures particle size by sedimentation?

104. Vigabatrin’s antiepileptic activity is due to:

105. Which anti-arrhythmic pairing is incorrect?

106. 2,5,8,11,14,17,20,23,26-nona-oxaoctacosan-28-yl p-(butylamino)benzoate is known for:

107. Which orally active testosterone derivative has progestational activity?

108. When one reactant is in great excess, the reaction is:

109. Glucose treated with nitric acid yields:

110. The wavelength of maximum absorption is called:

111. Artificial (synthetic) seeds are produced by:

112. A differential manometer is advantageous because it can:

113. What resolution is needed to separate C19H7N+ and C19H5O+ in MS?